What are the contraindications of simvastatin?
Simvastatin is contraindicated in patients with active hepatic disease including cholestasis, hepatic encephalopathy, hepatitis, jaundice or unexplained persistent elevations in serum aminotransferase concentrations.Click to see full answer. Subsequently, one may also ask, what can you not take with simvastatin? Avoid the use of grapefruit products. Avoid eating foods high in fat or cholesterol, or simvastatin…
Simvastatin is contraindicated in patients with active hepatic disease including cholestasis, hepatic encephalopathy, hepatitis, jaundice or unexplained persistent elevations in serum aminotransferase concentrations.Click to see full answer. Subsequently, one may also ask, what can you not take with simvastatin? Avoid the use of grapefruit products. Avoid eating foods high in fat or cholesterol, or simvastatin will not be as effective. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.Subsequently, question is, what are side effects of simvastatin? Common side effects of simvastatin include: CPK elevation (greater than 3x ULN) Constipation. Upper respiratory infection. Gas (flatulence) Transaminases increased (greater than 3x ULN) Headache. Muscle pain, muscle damage, or muscle weakness. Eczema. Also know, what are contraindications for statins? HMG-CoA reductase inhibitors (statins) Examples include Atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin. Contraindications include hypersensitivity, active liver disease, pregnancy, lactation, coadministration with strong CYP3A4 inhibitors (selected statins)What drugs does simvastatin interact with?Some products that may interact with this drug include: “blood thinners” (such as warfarin), cyclosporine, danazol, daptomycin, gemfibrozil. Other medications can affect the removal of simvastatin from your body, which may affect how simvastatin works.
